tag:blogger.com,1999:blog-25142322981042477192023-10-26T06:17:29.852-07:00Hubbard Foundation, CCSVI, and HealthBlog/Newsletter sharing insight regarding CCSVI, diet, supplementation and health. Intended for informational purposes, not to replace the advice of your health care provider- see disclaimer.Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.comBlogger58125tag:blogger.com,1999:blog-2514232298104247719.post-29433081092097431032015-06-24T08:09:00.000-07:002015-06-24T08:09:23.568-07:00Brain Drain<br /><div class="MsoNormal">
2015 is a watershed year for our understanding of brain
drainage.<span style="mso-spacerun: yes;"> </span>A lymphatic system for the
central nervous system has been<a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14432.html"> discovered.</a><span style="mso-spacerun: yes;">
</span>For two centuries it was thought none existed, its absence the second pillar
of the blood-brain barrier. <span style="mso-spacerun: yes;"> </span>Now, a
full-fledged lymphatic network it has been identified microscopically, hidden
in the walls of the dural meninges of the venous sinuses that drain blood from
the brain into the internal jugular veins.<span style="mso-spacerun: yes;">
</span>The research also demonstrated the transport through these lymphatic
vessels of white cells, including T-cells, and CSF immune macromolecules.<span style="mso-spacerun: yes;"> </span>In 2015 another brain drainage system was
also <a href="http://jem.rupress.org/content/early/2015/06/09/jem.20142290.abstract">discovered</a>.<span style="mso-spacerun: yes;"> </span>Coined the glymph
system it permits the drainage of the interstitial fluid that surrounds brain
cells to flow out between the astrocyte foot pads surrounding CNS capillaries
and venules. <o:p></o:p></div>
<div class="MsoNormal">
Neuro-immunology will change, having failed for half a
century to document auto-immunity or in fact any direct attack by the immune
system on healthy myelin.<span style="mso-spacerun: yes;"> </span>The discovery
of a brain lymphatic drainage system opens a new front on the advances in
understanding brain perfusion and venous drainage.<span style="mso-spacerun: yes;"> </span>Do these newly discovered systems function
normally in multiple sclerosis? <o:p></o:p></div>
<div class="MsoNoSpacing">
Few internal jugular venoplasties are performed for MS
currently, primarily because of the high re-stenosis rate, 30-50% of patients
have a return of their pre-venoplasty symptoms and ultrasound shows the vein
obstructed again.<span style="mso-spacerun: yes;"> </span>We are waiting for
better methods to keep the veins open.<span style="mso-spacerun: yes;">
</span>But why venoplasty helps so many patients is still an open
question.<span style="mso-spacerun: yes;"> </span>Does the discovery of the
brain’s lymphatic system, which drains into the internal jugular veins, provide
us clues?<span style="mso-spacerun: yes;"> </span>Previously it was theorized
that venous hypertension resulted from the jugular narrowing, or that sluggish
flow in the venules allowed red cells and iron to cross the blood-brain barrier
inciting inflammation.<span style="mso-spacerun: yes;"> </span>Now we can ask if
Paolo Zamboni’s theory of chronic cerebrospinal venous insufficiency is
associated with a lymphatic insufficiency as well. <span style="mso-spacerun: yes;"> </span>We can expect soon to know what cells and
proteins are passing through these lymphatics and how they affect the
oligodendrocytes that make myelin, and how lymphatic flow relates to venous
flow.<o:p></o:p></div>
<div class="MsoNoSpacing">
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<div class="MsoNoSpacing">
<a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14432.html">http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14432.html</a></div>
<div class="MsoNoSpacing">
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<div class="MsoNoSpacing">
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<div class="MsoNoSpacing">
<a href="http://jem.rupress.org/content/early/2015/06/09/jem.20142290.abstract">http://jem.rupress.org/content/early/2015/06/09/jem.20142290.abstract</a></div>
<div class="MsoNoSpacing">
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arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com3tag:blogger.com,1999:blog-2514232298104247719.post-3192980745238154932014-02-09T11:35:00.001-08:002014-02-09T11:35:17.523-08:00ISNVD FEB 9,2014ISNVD Feb 9,2014<br />
Day 2<br />
Nitric Oxide and Vascular Hypothesis in MS<br />
Dr Yulin Ge<br />
Diffuse Inflammatory activities<br />
NO<br />
inhibit mitochondria aerobic respiration and neurovascular coupling tiring out leas to decrease of oxygen consumption<br />
leading to hypoxia<br />
leading to hypo-perfusion an d to neuronal/axonal dysfunction and neurodegeneration<br />
<br />
apoptotic cell death of oligodendrocytes at later stages of lesion development<br />
measuring NO effects using MRI<br />
effects on oxygen metabolism<br />
effects on oxygen delivery<br />
Facts of oxygen metabolism in brain<br />
brain uses 20% of total oxygen<br />
oxygen delivery..<br />
oxygen consumption in MS is decreased<br />
oxygen metabolic abnormalities in MS measured with TRUST MRI<br />
why is there is less oxygen consumption in MS<br />
it's not only atrophy but it's because of the mitochondria has high levels of NO<br />
BOLD...<br />
CO2 like NO is a potent vasodilator and can cause increase of CBF<br />
compared to controls MS showed significantly decreased CVR<br />
The CVR defect inMS...impaired vasculaar regulation of blood flow supply or defective neurocoupling mechanism may affect effective oxygen delivery<br />
decreased CMRO2 in MS and decreased CVR inMS<br />
recent accumulating evidence of mitochondrial of/NO hypotheses in neuronal axonal tissure damage<br />
both O2 delivery and O2 uptake impairment can lead to chronic hypoxic condition<br />
NO is not the only mechanism that is responsible to neurodegeneration<br />
the increase in NO may be from the endothelium or microglia( as a result of infection) but either is due to inflammation<br />
<br />
Perfusion imaging in stroke<br />
Its current clinical status and its role in treating patients<br />
Dr Larry Latour<br />
<br />
there is insufficient evidence to support or refute the value of PWI in diagnosing acute ischemic stroke<br />
what is a mini stroke and being treated with tPA?<br />
15 minutes makes a difference in the treatment of an acute ischemic stroke. It is safe to reat even if it's a mimic of a stroke...as the treatment can prevent a stroke<br />
<br />
<br />
<br />
<br />
Hemodynamic impairment in MS...Imaging techniques and perspectives<br />
Yulin Ge<br />
vascular hypotheses has been around for numerous years<br />
pathology in MS...vascular<br />
perivascular inflammation...Dawson's finger...new lesions start around abnormal vessels<br />
first imaging sign of lesion formation<br />
BBB breakdown and increased permeability<br />
with effective anti inflammatory drugs<br />
first sign is prominent perivenular space using 7T MRI<br />
perfusion MRI<br />
detect abnormality before lesion<br />
increased perfusion in NAWN just before lesion formation<br />
venous dilation in initial inflammatory stage... priminet venules companied with increased perfusion<br />
enhancing lesion with increased perfuion<br />
new or recurred lesion activity that are not seen on conventional MRI<br />
the is hemodynamic impairment in MS<br />
fibrin deposition, small venous thrombosis, intimal hyperplasia<br />
there are lesions with different type of perfusion patterns<br />
significantly reduction of perfusion in deep GM in MS<br />
vascular component is critical in neurological disease<br />
MS patients with cardiovascular problems have increased MS problems<br />
<br />
<br />
<br />
<br />
SPECT and PECT perfusion changes after CCSVI restoration<br />
Paolo Zamboni<br />
<br />
diffuse hypo-perfusion in MS is a FACT. It cant be explained with autoimmunity but CCSVI is a valuable hypothesis<br />
hypo-perfusion precedes plaque formation approx 2 weeks earlier<br />
chronic plaques were more prevalent in WM regions with lower relative perfusion. can ccsvi be a strong contributor to hypoperfusion. may outflow restoration restore brain perfusion<br />
the data support a role of ccsvi in cerebral hemodynamic changes, such as a decreases of CBV and CBF regardless of diagnosis of MS<br />
theres is a relationship between brain perfusion and jugular flow<br />
flow reduction in and significant flow increase in collaterals<br />
the collateral veins drain blood respect to ED inflow to the head<br />
are the collateral veins filled by premature intra extra cranial anastomosis?<br />
hypo-perfusion may be consequence of blood shunting through meningeal arteries<br />
pilot study with 5 ccsvi cases...not only MS<br />
used PET scan.<br />
3 patients who improved with venoplasty ...one of them had Huntington disease had improvement of perfusion<br />
pilot study 2 using SPECT using open angioplasty<br />
8 ccsvi cases<br />
vast majority of patients improved flow<br />
PET and spect both reliably detect change in perfusion in ccsvi<br />
spect demonstrate hypoperfusion in ccsvi<br />
the procedure seems to cause significant improvement<br />
<br />
<br />
The rest of the morning session was devoted to traumatic brain injury:<br />
<br />
Abstract...cerebral hemodynamic changes in mild traumatic brain injury at the acute stage<br />
<br />
Abstract...altered IJV hemodynamics and impaired cerebral auto-regulation in patients with panic disorder<br />
PD patients have decreased IJV lumen<br />
<br />
Traumatic brain injury and vascular consequences<br />
state of the art understanding the fundamental physiology of TBI...from research to treatment<br />
<br />
Dr Ramon Diaz Arrastia<br />
single most common cause of death and permanent disability in young people under 45<br />
10%-15% of pts with TBI have micro blood vessel injuries<br />
there is also diffuse meningeal injury<br />
chronic mild tB of retired professional boxers<br />
cerebral blood flow is normal but the reactivity of the blood vessels is impaired<br />
Treatment:<br />
Sildenafil,erythropoietin, statins, G-CSF, VEGF, pioglitazone, exercise , enriched endothelia progenitor cells, from cord blood or bone marrow, low level laser light therapy, Infrared can penetrate the skull.<br />
It has anti inflammatory properties and promotes angiogenesis and releases NO<br />
people who have had TBI in early life have an increased risk of dementia in later life.<br />
<br />
<br />
Typical vascular lesions of TBI and their evolution<br />
Dr Gunjan Parikh<br />
brain micro vascular tree<br />
the first thing hit is the dura and cortex<br />
prospective study of acute TBI in the ED with blood on clinical CT or on MR<br />
256 subjects had indications of hemorrhage<br />
all were considered mild TBI<br />
<br />
<br />
<br />
The clinical spectrum and natural history of TBI Sequelae<br />
Dr Karen Tung<br />
<br />
role of perfusion and SWI in TBI<br />
how TBI and how it relates to the micro vasculature of the brain<br />
neurovascular unit NVU<br />
TBI damages the vessel wall or causes impaired perfusion and cause tissue ischemia<br />
BBB dysfunction results in edema and may affect protein clearance and accelerate brain aging or disease pathology<br />
<br />
<br />
State of the Art...the role of imaging and venous abnormalities in TBI<br />
Dr Zhifeng Kou<br />
<br />
Abstract...Hemorrhagic lesions based on venous and arterial damage and its clinical correlation in Traumatic Brain Injury<br />
Hardik Doshi<br />
<br />
<br />
Abstract...Thalamic Shape and Cognitive performance in amnesic mild cognitive impairment<br />
Hyun-kook Lim<br />
<br />
It is my understanding that the ISNVD will provide summaries of each of the presentations in a few weeks.<br />
<br />arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-79466159675560590512014-02-08T15:20:00.003-08:002014-02-08T15:20:27.583-08:00ISNVD Feb 8,2014 ISNVD Feb 8, 2014<br />
Session I. A multi-Modality Approach to Extra Cranial Venous Disease<br />
Dr Zivadinov session chairperson<br />
1. The Current Status of Ultra sound Imaging for the Screening of CCSVI...Dr Marcello Mancini...Univ. Naples<br />
ccsvi can be non invasively diagnosed by combined transcranial and extracranial echo doppler<br />
CCSVI more frequent in MS than in normal controls<br />
Italian study 1800 subjects<br />
the assessment of CCSVI was highly operator dependent... the echo color doppler is an ideal tool for assessing cerebral venous return<br />
<br />
What is the Normal Jugular Vein Valve Function?....Dr Erica Menegatti<br />
using echo doppler they were able to see the motility of the IJV valve leaflets in healthy volunteers<br />
findings 50% showed absent valve on 1 side<br />
in healthy subjects in IJV leaflets are always mobile and open in up right position<br />
62% of HC with valve absence at least of one side suggests a progressive loss of motility.<br />
<br />
<br />
Prevalence of Extracranial Venous Narrowing on Catheter Venography in pwMS<br />
Dr.Lindsay Machan<br />
CCSVI more prevalent in pwMS?<br />
BC Saskatchewan study...published in Lancet<br />
evaluate the frequency of venous stenosis in pwMS vs controls, and siblings of MS patients.<br />
ultrasound trained in Ferrara and used the Zamboni criteria<br />
the subjects were blinded<br />
the venography protocol was developed with Gary Siskin, MD and an SIR discussion group<br />
standardized upright and supine venography measures<br />
no significant differences in each group but MS patients felt moderately better.<br />
Dr Zamboni challenged this study!!!!<br />
<br />
Identifying CCSVI with Cervical Plethysmography<br />
Paolo Zamboni<br />
measured in normal controls<br />
hydrostatic gradient in cerebral venous outflow<br />
upright there is negative hydrostatic pressure<br />
zero hydrostatic pressure in supine<br />
posture shows restricted venous outflow in ccsvi vs normal when the system is stressed through change in position<br />
the system fills up quicker because the outlet pathways are restricted in CCSVI<br />
<br />
<br />
Diagnostic Contributions of Catheter Venography for Screening of CCSVI<br />
Dr Hector Ferral<br />
limitations of catheter venography is radiation exposure contrast media and may miss subtle issues.<br />
review the Venographic protocols of CCSVI<br />
reviewed 8 papers.<br />
R femoral vein is the easiest access<br />
power injection most popular<br />
Delayed emptying is an important criteria...greater than 6 sec is severe<br />
patients with severe stenosis had emptying between 6 and 27 sec<br />
proposal:<br />
r femoral vein( Dr Zamboni said in PPMS the L entrance is better)<br />
catheter straight multi-perforated<br />
contrast depends on IVUS availability<br />
injection...Power injector<br />
position of pt is supine<br />
multimodal approach is important<br />
<br />
What Additional information Can Intravascular ultrasound Provide?<br />
Adnan Siddiqui<br />
looked at azygos and IJV<br />
blinded evaluations<br />
IVUS is the best evaluation tool and was compared to catheter venography<br />
<br />
Molecular Markers of Abnormal CNS Hemodynamics<br />
Dr. Steven Alexander PhD<br />
endothelial cells are important they create the bBB<br />
abnormal pressure patterns.. links to neurodegenerative disease.Vascular stress is related to neurodegenerative disease. intra abdominal hypertension disturbs BBB<br />
endothelial cells under shear or stress release micro-particles can affect distant gene expression<br />
APP is associated with neurovascular disease and is a precursor to amyloid<br />
oscillating shear causes increased APP which is released into the brain.<br />
altered pressure can rapidly and reversibly modulate BBB<br />
Different shear patterns alter brain endothelial transcription factors<br />
Some transcription factors and microRNA's between cells as a novel form of distant site epigenetic modification<br />
APP is released by brain endothelial cells and is packaged into micro-particles<br />
Differential transfer of APP laden micro-particles may contribute to several forms of neurovascular degeneration<br />
<br />
State of the Art1: Why we need a multi-modality diagnostic approach for CCSVI<br />
MR, catheter venography, ultra sound, and IVUS all have positive aspects.<br />
PREMISE study used a multi-modality approach<br />
ISNVD has a position statement for the screening for diagnosis of CCSVI<br />
Two abstracts were presented:<br />
Abstract 1: Extracranial brain draining veins in a mouse: Assessment by high resolution ultrasound and MR angiography of the neck<br />
Brain drains from the external jugular in the mouse and in humans it is IJV's<br />
<br />
Abstract 2: Inverse relationship between IJV narrowing and increased brain volumes in healthy individuals<br />
IJV narrowing has been implicated in CNS pathologies<br />
Similarly brain volume reduction...atrophy...has also been linked to CNS pathologies<br />
However, IJV narrowing and atrophy have never previously been linked<br />
Assessment of the relationship between IJV CSA and atrophy in healthy individuals<br />
the hypothesis is increased narrowing...stenosis...would correlate with increased atrophy...reduced brain volume<br />
Secondary outcome is assessment of age effects and cervical location on these potential associations<br />
IJV narrowing was not associated with brain atrophy...mechanism unknown<br />
Dr Ziv Haskal Moderator<br />
Designing an endovascular trial...What elements are essential and why CCSVI trials might differ from Disease Modifying trials<br />
Dr Kottil W. Rammohan...Neurologist Univ. Miami(director of MS center)<br />
what is the short term effect of the procedure<br />
Long term benefits....as a stand alone or adjunct to a disease modifying treatment (DMT)<br />
any trial has to be blinded<br />
no trials have been done that meets the test of Cochran Review .<br />
Essential elements of all clinical trials.<br />
evidence, population, intervention. comparison, outcome , time (EPICOT)<br />
Defining CCSVI is the biggest problem<br />
Should use ambulation as an evaluation tool<br />
"having an open label trial is unconscionable"<br />
<br />
<br />
State of the Art :Current results of safety and efficacy of CCSVI therapy in MS patients<br />
Gary Siskin (Dr Dake presented)<br />
studies have demonstrated very low adverse events with venoplasty. It is a very safe procedure<br />
Efficacy<br />
improvement in a majority of patients but not all. Patients with severe delayed flow did not do as well as those with moderately delayed flow<br />
EDSS at one month and one year significantly improved<br />
cutting balloons are safe for those patients who had failed venoplasties.<br />
<br />
<br />
<br />
Procedural Endpoints. How to Best measure Meaningful Flow Impairment, Inter and Post Procedural Therapy<br />
Hector Ferral<br />
IVUS Driven Intervention..provides accurate information of vascular pathology shows, webs, valves, dissection, intramural problems.<br />
Optimizing Pure Venographic Therapy : there is no validated approach<br />
<br />
Intervention Studies in 2014<br />
The Time is Ripe for Primary and Replicative Therapy Trials in MS<br />
Ziv Haskal<br />
science is not linear, often not in types of therapeutics<br />
what happened in MS and CCSVI?<br />
the venoplasty is less dangerous than present treatment (DND's)<br />
it's time for more research<br />
<br />
Therapy Trials Need to Wait. The Landscape has changes<br />
Dr Kottil W. Rammohan<br />
Are we ready to do a randomized controlled trial? Dr Zamboni's trial was replicated by Dr Troulbasse and could not reproduce the same results in Vancouver. <br />
Dr Hubbard and challenges Dr Rammohan and says MS has not been proven to be immune modulated. <br />
<br />
Abstract 3...A report of 4 cases of anterior cranial fossa dural arteriovenous fistula: surgical consideration and technique using intraoperative indocyamine green angiography.<br />
Kuhyun Yang,MD<br />
<br />
<br />
Abstract 4...Classification of venous outflow in the extracranial vessels in a large cohort of MS patients.<br />
Sean Sethi...with Dr Haacke's research group<br />
4th study showing abnormal flow in the IJV<br />
used MRi and assessed the the IJV<br />
MS subjects wer classified as stenotic or non stenotic<br />
did flow quantification at c2/c3 and c5/6<br />
61% of the MS were stenotic<br />
<br />
CCSVI and Parkinson's<br />
Mark Haacke<br />
In MS patients, iron deposition occurs in both the basal ganglia and midbrain similar to what is seen in idiopathic Parkinson's Disease.<br />
23 PD patients and 23 Normal Controls<br />
there are abnormal structural and flow findings in PD patients.<br />
<br />
Etiologies of jugular venous abnormalities in transient monocular blindness<br />
Dr Chun-Yu Cheng<br />
sudden painless transient visual loss<br />
there is venous outflow resistance in the IJV<br />
IJV stenosis is found in in transient monocular blindness<br />
<br />
Age Related White Matter Changes, Alzheimer's Disease and Jugular Venous Reflux<br />
Dr Clive Beggs<br />
Pilot study and IJV reflux.<br />
JVR is associated with age related white matter changes, particularly in posterior brain regions.<br />
12 pts with AD 17 healthy controls 24 mild cognitive impairment<br />
dirty appearing white matter is a region of intermediate signal intensity between that of T2 lesions which may develop into lesions later on.<br />
AD patients had significantly reduction of dirty white matter, and increased lesion formation<br />
<br />
JVR and brain atrophy<br />
increased brain volume in grey and white matter...<br />
venous blood pooling is a possiblity<br />
<br />
Cerebral venous drainage impairment in idiopathic intracranial hypertension<br />
Dr Noam Alperin<br />
venous drainage in supine and upright postures<br />
in the upright posture, venous drainage shifts from the jugular to secondary veins and is significantly less pulsatile<br />
<br />
Headache and venous abnormalities<br />
Dr Wei-Ta Chen<br />
vein related cerebrovascular disorders with headache<br />
cerebral venoos thrombosis<br />
vasculitis<br />
arteriovenous malformation<br />
dural arteriovenous fistula<br />
carotid cavernous fistula<br />
Headache disorders with venous abnormalities<br />
idiopathic intracranial hypertension<br />
spontaneous intracranial hypotension<br />
migraine.<br />
IIH is not benign...they may lose vision<br />
treatment IIH<br />
endovascular stenting is one tx option<br />
spontaneous intracranial hypotension=<br />
orthostatic headache, neck tightness, subjective hearing symptoms<br />
evidence of CSF leakage on imaging<br />
TX of SIH:<br />
bed rest, hydration, epidural blood patch<br />
Migraine<br />
unilateral, throbbing,associated symptoms are nausea, photophobia and phonophobia, duration 4-72 hrs<br />
aura...visual, sensory, aphasia,motor<br />
if you compress bilat IJV it can make migraine worse.<br />
IJV volume increases during attack<br />
decreased in IJV compliance in migraine<br />
venous hypertension occurs during a migraine<br />
<br />
<br />
<br />
venous abnormalities involve in high altitude associated neurological disorders<br />
Dr Mark Wilson<br />
what happens when you are gradually exposed to increased altitude?<br />
can get a headache, mountain sickness or<br />
high altitude cerebral edema<br />
those with HA's had large venous sinuses<br />
being in space is not good for your eyes due to venous hypertension<br />
<br />
Cerebral venous drainage impairment and cerebral small vessel disorders<br />
Dr Han-Hwa Hu<br />
CVDI linked to small artery disease<br />
association with impaired cerebral auto-regulation<br />
association with lacuna stroke<br />
association with white matter diseases<br />
<br />
There were a couple of presentations that followed but because of my "brain overload" I decided to take a break.<br />
Will post again tomorrow!<br />
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<br />arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-50520042923662784292014-02-08T06:52:00.002-08:002014-02-08T06:52:20.519-08:00ISNVD 2014 KeynoteISNVD 2/14 Conference<br />
Day I<br />
Meeting and greeting so many remarkable people is such an inspiration. The energy in the room has been palpable. I think there will be a lot of excellent science presented at this conference if the keynote address is any indication.<br />
I'm posting this as the notes I took at the presentation. I apologize for abbreviations, poor sentence structure etc but I wanted to share ASAP.<br />
Keynote speaker...Dr. Paula Grammas PhD<br />
<br />
The Role of Blood Vessels and Inflammation in the Pathogenesis of Neurological Disorders.<br />
Texas Alzheimer's research and care Consortium...Director<br />
<br />
brain endothelial cells<br />
bbb function<br />
synthetic/metabolic capabilities...brain has more vasculature than any other part of the body<br />
<br />
the tight junctions of the bbb are very important<br />
the brain endothelial cells are very important metabolically<br />
endothelial cells actively regulates the neruonal micro environment<br />
neurpathological and neuroimaging studies indicate that 1/3 AD cases are complicated by vascular problems<br />
<br />
AD and CVD...inflammation, oxidative stress and apoE4 expression common to both AD and CVD...<br />
endothelial cells are widely recognized as key players in development of neurologic disease<br />
brain endothelium produces toxins in brain in AD<br />
blood vessels in AD...?<br />
NO can be toxic to neurons in high doses. NO is made by endothelial cells and in small amts. is fine. in AD these cells become abnormal<br />
AD vessels an over expression of iNOS and is usually not present in endothelial cells. this iNOS is very toxic in large amounts....caused by stress and inflammation<br />
micro vessels in AD are inflamed<br />
something is making the endothelial cells make inflammatory proteins<br />
Thrombin is an inflammatory protein and is found in the AD brain in the micro vessels and CSF...inflammation in the vessels has been found in AD<br />
vascular activation and angiogenesis have been documented in the AD brain<br />
no new blood vessels in the AD brain...what does that mean?<br />
vascular activation as a target for AD therapeutics<br />
animal studies are being done now...<br />
animals have been given a Pfizer drug (Sunitinib) causing angiogenesis have improved the animals cognitive abilities<br />
in vitro Sunitinib improves the function of the endothelium<br />
possible trigger for vascular activation is hypoxia<br />
a key mediator in both angiogenesis and hypoxia is Thrombin<br />
Thrombin inhibitors improve the function of the mice<br />
"what's good for the heart is good for the brain"<br />
While waiting for the cure of AD take care of any causes of inflammation (ie Diabetes) with diet and exercise.<br />
Hypoxia stimulates the endothelial cells to create a host of inflammatory messengers designed to cause angiogenesis (creation of new blood vessels). So why is there hypoxia? Is the hypoxia chronic or intermittent? These are some questions that need to be answered!<br />
Looking forward to the first full day of learning!<br />
<br />
<br />
<br />arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-80738853411882966932013-09-28T12:12:00.000-07:002013-09-28T12:45:55.927-07:00The Gut Brain Connection<!--[if gte mso 9]><xml>
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<span style="font-size: 16.0pt;">Gut Brain Connection<o:p></o:p></span></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
<span style="font-size: 16pt;">Hippocrates said “All diseases begin in the
gut”!<o:p></o:p></span></div>
<div class="MsoNormal">
<span style="font-size: 16pt;">Our western culture’s love of processed foods,
the use of antibiotics in our dairy and meats and GMOs have led to a
destruction of our friendly gut flora.</span> <span style="font-size: 16.0pt;">Pain
relievers, such as aspirin and NSAIDS, and steroids also damage the gut flora.
Birth control pills, sleeping pills, GERD medications and numerous other drugs
cause problems within the GI tract.<o:p></o:p></span></div>
<div class="MsoNormal">
<span style="font-size: 16.0pt;">Eating a diet filled with too
much simple carbohydrates, sugars and processed foods increases the fungi that
live in our gut flora. If the fungi and “bad bacteria” outnumber the beneficial
bacteria we are prone to develop disease.<o:p></o:p></span></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
<span style="font-size: 16pt;"> According to <a href="http://www.youtube.com/watch?v=Z_0NvcJZwa8">Natasha Campbell-McBride MD</a>,
neurologist and author of <u>The Gut and Psychology Syndrome</u>, there are dietary
measures for restoring a healthy gut.
She recommends taking a probiotic supplement and a diet that includes
food sourced probiotics from fermented foods and water and milk kefirs.<o:p></o:p></span></div>
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<span style="font-size: 16pt;">Eating fermented foods on a
regular basis is the most effective way to heal a “leaky gut”, a condition that
exists because of a weakened and often inflamed, permeable intestinal membrane,
which allows undigested food particles to enter the blood stream.<o:p></o:p></span></div>
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<br /></div>
<div class="MsoNormal">
<span style="font-size: 16pt;">The <a href="http://newsroom.ucla.edu/portal/ucla/changing-gut-bacteria-through-245617.aspx">science</a> is there, we
are what we eat and we can heal ourselves with the help of fermented foods.<o:p></o:p></span></div>
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<br /></div>
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<br /></div>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-39307058066038749152013-09-12T08:50:00.002-07:002013-09-12T08:50:32.860-07:00September FDA UpdateWe had expected to receive a response from the FDA the day after Labor Day but did not. David called the FDA on September 3rd and spoke to one of the reviewers who was very friendly. She said we were down to minor issues and sent the document to us. This latest deficiency notice focused on the frequency of adverse events noted in the literature and, once again, said they recommended but do not require a sham control group. Once again, we explained that patients had to pay for this treatment themselves and were certainly not going to pay for a sham treatment. David called the agency again to ask why they keep asking the same question each month and the reviewer he spoke to said they understood that we couldn't provide a control arm but "we're required by congress" to mention study design considerations in all correspondence. <br />
<br />
Of course a double blind placebo controlled trial is the only way to prove once and for all if venoplasty helps MS patients but this is a very difficult and expensive study to do. We sympathize with Dr Siskin that he had difficulty recruiting subjects who might only get a sham procedure.<br />
<br />
Our philosophy with the Registry is to continue collecting data and improving venoplasty technique under the auspices of the FDA to keep up the momentum until such a double blind placebo controlled study can be done.<br />
<br />
Here is a very brief summary of where we stand with the FDA:<br />
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; font-family: Helvetica;"></span><br />
<blockquote type="cite">
<div dir="ltr">
<div class="gmail_default">
<span style="font-family: arial, sans-serif; font-size: 12.571428298950195px;"> It's not funded, patients or their insurance must pay for the procedure. There are ultrasounds before and at 1 week and 1, 6 and 12 months. The FDA is also allowing only one brand of stent under clearly constrained circumstances, and requiring that patients have an EDSS score before and at 12 months. Otherwise it's pretty straightforward quality-of-life and adverse event form completions. Approximately 100 people have expressed interest in participating and a group of very experienced interventional radiologists around the country are waiting to begin ( we're not posting their names yet until they have a chance to review the final FDA requirements).</span></div>
</div>
</blockquote>
<div>
<div dir="ltr">
<div class="gmail_default" style="color: #000099;">
<span style="font-family: arial, sans-serif; font-size: 12.571428298950195px;"><br /></span></div>
</div>
</div>
arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-38822478392160611552013-08-31T12:23:00.002-07:002013-08-31T12:23:39.576-07:00Decrease your inflammation
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<b>Inflammation Information </b><o:p></o:p></div>
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The evidence seems incontrovertible that low grade
inflammation weakens the brain endothelium and promotes neurodegeneration. For
a thorough review see Dr David Perlmutter’s article:<span style="font-size: 12pt;"><o:p></o:p></span></div>
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<span style="font-family: Arial; mso-bidi-font-size: 14.0pt; mso-bidi-font-weight: bold;">The Role of Inflammation in Neurodegenerative
Disorders: Integrative Approaches to Challenging Neurological Disorders</span><o:p></o:p></div>
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<a href="http://www.worldhealth.net/pdf/bookstore/aamt_vol7_30_perlmutter.pdf">http://www.worldhealth.net/pdf/bookstore/aamt_vol7_30_perlmutter.pdf</a><o:p></o:p></div>
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Dhttp://drperlmutter.com<o:p></o:p></div>
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An anti-inflammatory diet and lifestyle change (stress reduction,
exercise, gluten free/Paleo diet) are critical for endothelial health.
Anti-inflammatory foods help to keep the immune system in balance and not
over-inflame when stimulated. To effectively decrease inflammation it is
essential to completely avoid man-made
foods, sugars, gluten and food allergens. <o:p></o:p></div>
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Anti-inflammatory
foods include, but are not limited to coconut products, berries, and
non-denatured, whey protein from grass-fed cows and goats. Anti-inflammatory
herbs such as turmeric, ginger, boswellia, cinnamon, rosemary, & oregano
among others should be used as much as possible.<o:p></o:p></div>
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Naturally fermented foods such as red cabbage sauerkraut,
kimchi, & coconut kefir are excellent foods for restoring healthy gut
bacteria.which is essential in decreasing inflammation. Additionally, a high quality probiotic
supplement with 50+ billion microorganisms should be consumed regularly.<o:p></o:p></div>
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http://www.naturalnews.com/038915_inflammation_foods_healing.html<o:p></o:p></div>
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A balanced immune response in the body is also dependent
upon healthy vitamin D levels. Vitamin D helps the body recognize between
foreign and self proteins. This reduces inflammation and auto-immune
reactions.Healthy Vitamin D3 levels should be between 60-100 ng/ml. Be sure to
get tested and supplement if necessary.<o:p></o:p></div>
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The Hubbard Foundation believes that people should be tested
for low grade inflammation. These are some tests you might consider:<o:p></o:p></div>
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Vitamin D…25(OH)D<o:p></o:p></div>
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http://www.vrp.com/single-vitamins/vitamin-d3-deficiency-linked-to-a-surprising-number-of-health-concerns<o:p></o:p></div>
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Oxidized LDL <o:p></o:p></div>
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http://cholesterol.about.com/od/lipoproteins/f/oxidizedldl.htm<o:p></o:p></div>
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High sensitivity C-reactive Protein<o:p></o:p></div>
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http://www.nlm.nih.gov/medlineplus/ency/article/003356.htm<o:p></o:p></div>
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Homocysteine<o:p></o:p></div>
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Here’s some more information:<o:p></o:p></div>
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http://drbenkim.com/articles-homocysteine.html<o:p></o:p></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">To help decrease
inflammation we recommend the use of Tumeric (curcumin is the main
anti-inflammatory component of Tumeric).<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12676044">http://www.ncbi.nlm.nih.gov/pubmed/12676044</a><o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">You can make a
delicious tea which you can drink hot or cold throughout the day:<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Add the juice of a
lemon or lime to a cup of hot water. Add a few slices of fresh ginger, a
sprinkle of turmeric and cayenne with a little bit of Stevia ….if you like your
tea sweet.<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">In addition, you can
add some supplements such as:<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Nrf2 activator<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Omega 3 <o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Neprinol (systemic
enzymes which help to thin the blood by removing fibrin)<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Astaxanthin<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">We also recommend
eating lots of dark colorful vegetables, grass fed beef, free range chicken and
eggs. Ridding your diet of simple carbs like rice, pasta, bread and sugars you
can reduce inflammation.<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">We believe being under the care of an
integrative medicine, functional medicine or naturopathic doctor can be of
great benefit.<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">To find a naturopath
near you go to:<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">www.acam.org<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Here are some links for more information:</span></div>
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http://www.naturalnews.com/038915_inflammation_foods_healing.html</div>
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http://www.greenmedinfo.com/blog/are-mental-disorders-result-neuroinflammation</div>
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http://www.collective-evolution.com/2013/05/30/new-study-shows-cannabinoids-improve-efficiency-of-mitochondria-and-remove-damaged-brain-cells/#_</div>
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http://www.greenmedinfo.com/article/stevia-anti-inflammatory-and-immunomodulatory</div>
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<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-65105783650739076142013-06-29T11:15:00.000-07:002013-06-29T11:16:31.740-07:00Responses to comments on our June NewsletterAs most of you know we have been negotiating with the FDA since their warning letter in May 2012 to get their approval to continue our Registry which had already enrolled over 400 MS patients receiving venoplasty. In their most recent request for revisions they have asked that we add EDSS scores before and one year after the treatment. We agree that this is an additional burden and that EDSS scores are incomplete and inaccurate. However, we have no choice and, at least ,in the United States these neurology evaluations should be covered by insurance. We are aware that most insurance is presently not covering the venoplasty itself and patients will have to pay for this themselves. We have approximately 6 IRs that have been waiting to begin doing the procedure again when we get approval. They are listed on our web site where you can also let us know if you might be planning to participate. www.hubbardfoundation.org/participating-irsarleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-6738112988214879902013-06-26T14:18:00.003-07:002013-06-26T14:18:50.228-07:00Dimethyl Fumerate update
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">This week's Neurology
Today published a story on PML in patients taking dimethyl fumarate.
There have been a total of 4 patients in Europe. Each of the
patients had severe and prolonged lymphocytopenia - low lymphocyte counts in
their blood. All of them recovered after being taken off fumarates.
Severe lympocytopenia occurs in 3% of patients taking fumarates.
One of the patients had also been treated with methotrexate, another with
steroids. Robert Fox MD interviewed for this story thought that either
infection or a significantly altered immune system might be the culprit rather
than the fumarate itself. The cause of lymphocytopenia is not yet known,
especially since the mechanism of action of fumarates is suppression of oxidative
stress, not immunosuppression per se.<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Dr Hubbard has been
communicating with David Perlmutter,MD http://www.DrPerlmutter.com/ regarding
the dosage of Nrf2 activators with those with neurodegenerative disease. Dr.
Hubbard is<span style="color: #001684;"> </span>concerned that only one or two
tablets per day of the supplemental forms of fumarate derivatives is too low a
dose for MS patients.Both Drs Hubbard and Perlmutter are suggesting
patients push the dose to three or four tablets per day, or even to the point
of getting some flushing or nausea (common with Tecfidera) and then backing off
a until they feel better and that would be the working dose<span style="color: #001684;">.</span><o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">Dr Perlmutter also
suggested that instead of increasing the Nrf2 activator (Protandim or Xymogen
Nrf2 activator) patients may add more Turmeric and Sulforaphane along with the
product.<o:p></o:p></span></div>
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<span style="font-family: Helvetica; font-size: 12.0pt; mso-bidi-font-family: Helvetica; mso-fareast-language: JA;">When you are making any
changes to your medications or supplements you should always consult with your
trusted medical professional.</span><o:p></o:p></div>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-40567852229199035282013-04-28T09:37:00.003-07:002013-04-28T09:39:14.794-07:00Brain Healthy Decadence<!--[if gte mso 9]><xml>
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<b>Cacao Hazelnut Brain Bliss<o:p></o:p></b></div>
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<br /></div>
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Nearly all of the ingredients in this decadent spread are
beneficial for brain function. Check out the notes below for more information! <o:p></o:p></div>
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<br /></div>
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*2cups Hazelnut Butter<o:p></o:p></div>
<div class="MsoNormal">
1/3 cup cacao<o:p></o:p></div>
<div class="MsoNormal">
1/3 cup coconut oil<o:p></o:p></div>
<div class="MsoNormal">
20-30 drops Hazelnut Stevia (if you only have plain liquid
Stevia that should be fine)<o:p></o:p></div>
<div class="MsoNormal">
pinch of salt<o:p></o:p></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
Place all ingredients in a food processor and blend. <o:p></o:p></div>
<div class="MsoNormal">
Enjoy as a fruit dip, spread or the way I like it….by the
spoonful!<o:p></o:p></div>
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<br /></div>
<div class="MsoNormal">
Hazelnut butter<o:p></o:p></div>
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1lb raw hazelnuts. <o:p></o:p></div>
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<br /></div>
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Preheat oven to 350°<o:p></o:p></div>
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Roast for 10-15 min on a sheet pan.<o:p></o:p></div>
<div class="MsoNormal">
When cool, place in food processor with a pinch of salt.
Blend until smooth.<o:p></o:p></div>
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<br /></div>
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Benefits of Hazelnuts:<o:p></o:p></div>
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<span style="font-family: Verdana; font-size: 13.0pt; mso-bidi-font-family: Verdana; mso-fareast-language: JA;"> Hazelnuts are rich in vitamin B6 which is
necessary for nervous system function. In addition,B6 is necessary for the
creation of myelin, the insulating sheath of the nerve that increases the speed
and efficiency of electrical impulses, allowing the nervous system to operate
optimally. What's more, vitamin B6 is instrumental in the synthesis of the
neurotransmitters serotonin, <o:p></o:p></span></div>
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<span style="font-family: Verdana; font-size: 13.0pt; mso-bidi-font-family: Verdana; mso-fareast-language: JA;">melatonin, and
epinephrine.<o:p></o:p></span></div>
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<br /></div>
<div class="MsoNormal">
<span style="font-family: Verdana; font-size: 13.0pt; mso-bidi-font-family: Verdana; mso-fareast-language: JA;">Benefits of Coconut Oil:<o:p></o:p></span></div>
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<span style="font-family: Verdana; font-size: 13.0pt; mso-bidi-font-family: Verdana; mso-fareast-language: JA;">There are numerous
benefits of coconut oil (too many to explain here).<o:p></o:p></span></div>
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<span style="font-family: Arial; font-size: 12.0pt;">“There's
another substance that can feed your brain and prevent brain atrophy. It may
even restore and renew neuron and nerve function in your brain after damage has
set in.<o:p></o:p></span></div>
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<span style="font-family: Arial; font-size: 12.0pt;">Ketones
are what your body produces when it converts fat (as opposed to glucose) into
energy. And a primary source of ketone bodies are the medium chain
triglycerides (MCT) found in coconut oil!<o:p></o:p></span></div>
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<span style="font-family: Arial; font-size: 12.0pt;"><a href="http://www.healthdiaries.com/eatthis/8-health-benefits-of-hazelnuts.html">http://www.healthdiaries.com/eatthis/8-health-benefits-of-hazelnuts.html</a><o:p></o:p></span></div>
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<br /></div>
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<span style="font-family: Arial; font-size: 12.0pt;">Coconut oil
contains about 66 percent MCTs.”<o:p></o:p></span></div>
<div class="MsoNormal">
<a href="http://www.naturepacific.com/contents/en-us/d227_virgin-coconut-oil-brain-food-prevent-Alzheimers.html">http://www.naturepacific.com/contents/en-us/d227_virgin-coconut-oil-brain-food-prevent-Alzheimers.html</a><o:p></o:p></div>
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<br /></div>
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<br /></div>
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Benefits of Cacao:<o:p></o:p></div>
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<span style="font-family: Arial; font-size: 13.0pt;">“Flavanols
may act on the brain structure and function directly by protecting neurons from
injury, improving metabolism and their interaction with the molecular structure
responsible for memory researchers said. Indirectly, flavanols may help by
improving brain blood flow.”<o:p></o:p></span></div>
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<a href="http://www.sciencedaily.com/releases/2012/08/120813173205.htm">http://www.sciencedaily.com/releases/2012/08/120813173205.htm</a><o:p></o:p></div>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-91057446528940467322013-03-30T16:47:00.000-07:002013-04-09T14:00:20.136-07:00FDA announces approval of dimethyl fumarate<!--[if gte mso 9]><xml>
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<b><span style="font-size: 12.0pt;">Dimethyl Fumarate<o:p></o:p></span></b></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">On
March 27, 2013 Dimethyl fumarate has won FDA approval to treat
relapsing-remitting forms of multiple sclerosis and will be sold under the name
Tecfidera also known as BG-12, manufactured by Biogen Idec. <o:p></o:p></span></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">The
drug has been used for many years in Europe to treat psoriasis, and since the
1980’s as a fungicide.<o:p></o:p></span></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">Dimethyl
fumarate is unlike all previous MS “disease-modifying drugs” (DMDs) which all
work by eliminating T lymphocytes and/or preventing them from crossing the
blood-brain barrier. It thus represents
a “radical change in multiple sclerosis pathogenesis” according to van Horssen
a long-time leading MS researcher. Instead,
dimethyl fumarate is an “anti-oxidant” which means that it reduces “reactive
oxygen species” which in turn reduces free radicals. For years health
specialists have been extolling the importance of anti-oxidants such as green
tea and turmeric to delay ageing. But
recent research has demonstrated that the oligodendrocytes that make myelin are
extremely sensitive to free radicals. Dr. van Horssen reported at ECTRIMS in
2011 that dimethyl fumarate exerts its protective effect via activation of the
nuclear-factor-E2 (Nrf2) transcriptional pathway that is involved in the
production of antioxidant enzymes necessary for oxidative stress defense. He stated that distinct Nrf2 activators like
dimethyl fumarate boost antioxidant enzyme production in oligodendrocytes and
limit ROS-mediated oligodendrocyte death.<o:p></o:p></span></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">Two
placebo-controlled phase III trials served as the basis for the FDA approval. A total of about 2,700 patients were studied.
In addition to comparing the drug with placebo, dimethyl fumarate was also
compared to glatiramer acetate (Copaxone).<o:p></o:p></span></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">At
the 2013 annual meeting of the American Academy of Neurology Robert Fox, MD
reported that MRI T2 lesions were reduced by 72% at 6 months and 82% at two
years. Gadolinium-enhancing lesions were
reduced by 83% at 6 months and 83% at two years. This is much better than the
immunosuppressants drugs. It was also
superior to Copaxone.<o:p></o:p></span></div>
<div style="line-height: 15.0pt; margin-bottom: 11.25pt; margin-left: 0in; margin-right: 0in; margin-top: 0in; vertical-align: baseline;">
<span style="font-size: 11.0pt;">The
main side effect was gastrointestinal complaints. There has also been a case report of one 72
year-old man who developed PML on Fumaderm the name of the drug in Germany that
has recently been purchased by Biogen. <o:p></o:p></span></div>
<div class="MsoNoSpacing">
Biogen obtained a use patent for dimethyl fumarate in
2009. It is important to note this was a
“use” patent; Biogen did not invent dimethyl fumarate that has been available
for decades. They patented the
preparation of it in enteric-coated micro-tablets to reduce the GI irritation
in a dose designed to deliver approximately 100 mg of fumaric acid to treat
multiple sclerosis and other conditions.<o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
Dr. van Horssen also compared Biogen’s formulation called
BG-12 to Protandim, an over-the-counter Nfr2 activator dietary supplement in an
<i>in vitro</i> (human oligodendrocyte cells
in a petri dish, not <i>in vivo</i>,
skeptical and gullible human beings). He found that Protandim was actually superior
to BG-12, as the “most potent induction of Nfr2-driven antioxidant enzyme
production in oligodendrocytes” (ECTRIMs 2011). <o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
Biogen recommends taking the 120mg capsule twice daily,
increasing to two (2) twice daily after a few weeks. Based on their 2009 patent this would be
approximately 100mg of fumeric acid, but we are still looking into this
conversion question. Although Biogen has
not announced how much they will charge for their new drug, it is likely that
it will be about the same as the other DMDs, i.e. about $40,000 per year. Protandim is expensive but costs about $40
per month or $480 per year, but currently will not be reimbursed by insurance
companies. It contains several herbs
that are high in fumeric acid including green tea extract and turmeric
extract. The company that makes
Protandim typically recommends one tablet a day. David Perlmutter MD (author of “BrainRecovery.com”)
recommends that patients with neurodegenerative disorders such as MS take one
twice daily of another brand of Nfr2
Activator made by Xymogen which also contains green tea and turmeric extracts. One can take the herbs themselves but it will
be important to make sure that an adequate quantity is taken and there may be
more GI irritation at higher doses. Terry Wahls MD (author of “Minding My
Mitochondria”) recommends 3 cups per day of intensely colors vegetables and
fruits such as beets, carrots, squash, berries and peaches. Non-denatured whey
is also a source of anti-oxidant stimulation.
Ann Boroch CNC (author of “Healing Multiple Sclerosis”) also recommends
anti-oxidants ideally from foods but also several supplements including Antioxidant Supreme made by Gaia Herbs. We are continuing to look into the appropriate
conversion between Tecfidera and other formulations. Since Biogen has spent many millions to prove
dimethyl fumarate’s efficacy, it will be worthwhile to try to obtain adequate
quantities of similar Nrf2 activators from other formulations. <o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
Summary: A
multi-million dollar FDA trial has proven that taking Nfr2 activators
dramatically reduces MS. The mechanism
of action is the reduction of oxidative stress, not immunosuppression. This mechanism is in keeping with the
inflammation/brain vein drainage model (in contrast to the orthodox autoimmune
attack on intact myelin by T cells model).
We believe that everyone should be taking it, whether prescribed by
neurologists – Tecfidera, or by naturopaths – Protandim, Xymogen, diet, or
herbal supplements. <o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
<br /></div>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com6tag:blogger.com,1999:blog-2514232298104247719.post-4516556875796686942013-03-04T12:59:00.000-08:002013-03-04T12:59:36.130-08:00FDA Update<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; font-family: Helvetica;">Here's a brief summary of where we stand with the FDA to date: </span><br />
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; font-family: Helvetica;">May10,2012 FDA stops all CCSVI research</span><br />
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; font-family: Helvetica;">May17,2012 Hubbard Foundation requests an exemption from the FDA</span><br />
<span style="font-family: Helvetica;">Sept 15,2012 FDA responds with a list of recommendations</span><br />
<span style="font-family: Helvetica;">Jan 7,2013 Hubbard Foundation submits a formal IDE application</span><br />
<span style="font-family: Helvetica;">Feb 8,2013 FDA responds with additional recommendations.</span><br />
<span style="font-family: Helvetica;"> It does appear the FDA will approve our Registry to continue studying CCSVI in MS.</span><br />
<span style="font-family: Helvetica;"><br /></span>
<span style="font-family: Helvetica;">For those of you who are interested in having the procedure please see our map of IR sites who are ready to begin once we get FDA approval. </span>www.hubbardfoundation.org/CCSVI_locations.html<br />
<br />
Let's go with the flow!arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-87183442104172696772013-02-26T11:05:00.001-08:002013-02-26T11:05:10.784-08:00Benefits of Coconut OilCoconut oil has many health benefits. Lately we've been hearing about its use in boosting brain function.<br />
Look for extra virgin,unrefined,organic oil. See Dr Mary Newton's web site for more information on how to use coconut oil. http://www.nccdp.org/resources-coconut-oil.htm<br />
<br />
Here is my recipe for a yummy snack:<br />
<br />
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px; font-family: Helvetica;"></span><br />
<div class="MsoNormal" style="margin-bottom: 20pt;">
<b><span style="color: #0e0e0e; font-family: Georgia; font-size: 24pt;">Coconut Crack Bars</span></b><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;"><o:p></o:p></span></div>
<div class="MsoNormal" style="margin-bottom: 20pt;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">Makes 6-8 bars<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.5in;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">▪<span style="font-family: 'Times New Roman'; font-size: 7pt;"> </span></span><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">1 cup </span><span class="Apple-style-span" style="color: #0e0e0e; font-family: Georgia; font-size: 17px;">unsweetened</span><span class="Apple-style-span" style="color: #0e0e0e; font-family: Georgia; font-size: 17px;"> shredded coconut </span></div>
<div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.5in;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">▪<span style="font-family: 'Times New Roman'; font-size: 7pt;"> </span></span><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">1/4 cup coconut nectar or pure maple syrup <o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.5in;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">▪<span style="font-family: 'Times New Roman'; font-size: 7pt;"> </span></span><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">2 tbsp virgin coconut oil <o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.5in;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">▪<span style="font-family: 'Times New Roman'; font-size: 7pt;"> </span></span><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">1/2 tsp pure vanilla extract<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-left: 0.5in; text-indent: -0.5in;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">▪<span style="font-family: 'Times New Roman'; font-size: 7pt;"> </span></span><span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">1/8 tsp salt<o:p></o:p></span></div>
<div class="MsoNormal" style="margin-bottom: 20pt;">
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;">Combine all ingredients in a food processor. Press into any small container or square baking dish and refrigerate for an hour or freeze for 15 minutes. Remove and slice into squares. Enjoy!<o:p></o:p></span></div>
<div>
<span style="color: #0e0e0e; font-family: Georgia; font-size: 13pt;"><br /></span></div>
<br />
<br />arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-1392128955471556012012-10-28T15:53:00.000-07:002012-10-28T15:53:38.718-07:00Dr Hubbard's response to the 10-28-12 NY Times article "The Zamboni Effect. A controversial 'Cure' for MS"<h2>
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<div class="MsoNoSpacing">
“The Zamboni Effect. A Controversial ‘Cure’ for M.S” tells a bitter-sweet tale of four MS patients,
<i>Devin, Jeff, Elena and Adam</i>, their
families’ efforts to bring new light and hope to a mean and miserable disease, and
the demeaning response of neurologists. <i>Devin</i>
is my son and I am a neurologist, trained at Yale, Stanford, and Einstein where
I was chief-resident in 1982. When he
was diagnosed with MS I consulted my neurology colleagues, studied the research
literature and concluded that the orthodox explanation – immune T cells were
attacking normal myelin – was false, and that the $40,000/year drugs that
disable T cells offered little hope. My
wife Arlene found <i>Jeff</i>’s wife Joan on
her Facebook site where she had compiled a massive library of research on MS
and in particular the research publications of Zamboni, a vascular surgeon at
the University of Ferrara. Zamboni’s
wife <i>Elena</i> had been diagnosed a
decade earlier and since then he had rediscovered and re-invigorated a
different explanation - abnormal venous drainage from the brain and spinal cord
causing inflammation and damage to the myelin-making cells around the small
veins. Joan reached out to a courageous
vascular surgeon at Stanford who found obstructions in <i>Jeff</i>’s jugular veins and opened them with balloon catheters
inserted though the femoral vein in the thigh.
Today we are good friends; we have a new medical society, the
International Society of NeuroVascular Disease, and several charitable
foundations including CCSVI Alliance, the Annette Funicello Research Fund and
our own Hubbard Foundation.<o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
The hostile and demeaning response from the neurologists
is the underlying theme of the NYT story and its subtitle, “just experiencing
the power of suggestion?” Neurologists
stopped the Stanford surgeon from continuing his research and have lined up for
a law suit against him. A Cleveland Clinic neurologist says “it offers false
hope.” A Dutch neurologist is quoted
saying my own review of 259 cases published this year in the Journal of Vascular
and Interventional Radiology has zero scientific value; he apparently also told
the reporter he believes MS complaints are mostly “psychological.” The FDA announced last May that any
researcher on venoplasty must apply for their approval (our Foundation has done
so). The story begins and ends with <i>Adam</i> whose brother Chris is a
neurologist at Yale. Chris is quoted as
saying “It’s one of the saddest and most outrageous stories of scientific
misconduct,” provocative language against authors of peer-reviewed scientific
journals challenging the status quo. I
found some publications by <i>Adam</i>’s
brother on cocaine dependence, but none on MS (his website states he
specializes in Botox for headaches). When learning that a fellow MS patient was
seeing his brother, <i>Adam</i> says, “poor guy,” echoing the feeling of many patients who
have stopped seeing neurologists.. <o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
<div class="MsoNoSpacing">
Here’s what we say to patients and their families:
consult a vascular specialist to investigate your blood flow/perfusion; consult
an integrative medicine specialist to investigate inflammation and toxins, but
above all, don’t let the neurologists get you down!<o:p></o:p></div>
<div class="MsoNoSpacing">
<br /></div>
</h2>
<h3>
<o:p> </o:p></h3>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com55tag:blogger.com,1999:blog-2514232298104247719.post-28428351833723872892012-10-03T13:41:00.000-07:002012-10-03T13:41:59.725-07:00ECTRIMS Abstracts on CCSVI 2012
<br />
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"> </span><span style="background-color: white; font-family: Arial; font-size: 11pt; font-weight: 700;">ECTRIMS Abstracts on CCSVI 2012</span><br />
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Reviewed by David Hubbard MD, Hubbard Foundation
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Summary<br />
Very brief summaries of each abstract are presented below. First we summarize the highlights:
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">There is an abstract from a doctor in Kuwait reporting that patients were actually worse 1
year after treatment. Here is an email to me from Tariq Sinan MD, the lead author of the work
referred to in this abstract.
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<span style="color: rgb(13.333000%, 13.333000%, 13.333000%); font-family: 'ArialMT'; font-size: 10.000000pt;"><br /></span>
<span style="color: rgb(13.333000%, 13.333000%, 13.333000%); font-family: 'ArialMT'; font-size: 10.000000pt;">Oct 1, 2012<br />
Dear David,<br />
Absolutely. you can forward my emails to anybody you want.<br />
Furthermore his poster is not just repudiated. its illegal. he did not get permission neither from all
investigators nor from the Kuwait research authorities. All papers and results have to be approved
by them. same paper was rejected from ANM after we wrote to them. The author in his poster is not
even part of the study team.<br />
Dr. Alrougani met less than 30 % of patients once only. the rest of the patients refused to go to him
because they thought he was biased. We used another Neurologist. its now more than 2 years since
we started the study. 70% of patients feel they have benefited from the procedure. 1 patient got
worse, he got thrombosis in one vein and the neurologist thought he got worse because he stopped
Tysabri suddenly.<br />
We hope our 2 yrs follow up prospective study will be out soon.<br />
Best regards,<br />
Tariq Sinan. MD Kuwait
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">The British Columbia CCSVI Registry reported that most patients who had the treatment said
it “met their overall expectations,” and that there were no serious adverse events.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Zivadinov reported that venoplasty improved CSF flow.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">A method not previously studied, called transcranial brain photplethysmography, may shed light
on what is happening in the brain microcirculation.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Thirteen of the 21 abstracts were ultrasound studies and predictably were negative,
inconclusive, and/or repetitive. I think we have all learned that ultrasound is not able to provide
diagnostic criteria for the hypothesis of chronic cerebro-spinal venous insufficiency, and internal
jugular ultrasound will not help us understand what is happening in the small veins of the CNS
white matter where MS lesions occur.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Abstracts in the order listed by ECTRIMS:
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Panczel etal. Hungary<br />
20 aneurysm patients and 14 MS patients were tested with Doppler and DSA. Normal flow was
found leading the authors to conclude that their DSA findings were "not real," and explained by
dilution by flow from the subclavian vein.
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Trufyn et al. British Columbia Group<br />
Burton's group found "incidental findings" such as thyroid cysts on MRI of brain and neck in 22
of 156 MS patients.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Yee et al. British Columbia CCSVI Registry<br />
Of 50 MS patients interviewed by phone, 68% said their venoplasty "met their overall
expectations. 5 patients reported minor complications including 1 hospitalization for arrythmia.</span><br />
<span style="font-family: ArialMT; font-size: 11pt;"><br /></span>
<span style="font-family: ArialMT; font-size: 11pt;">Diaconu et al. Fox's group at Cleveland Clinic</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">
11 MS patients and 5 normals had additional ultraounds. 5 of 7 subjects with abnormal
ultrasounds became normal after hydration.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Wolinsky et al. Houston MS Clinic<br />
3.88% of 206 MS patients and 7.14% of normals met CCSVI ultrasound criteria, that correlated
poorly with MRV findings in a sub-group of 83 patients.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Alroughani and Lamdhade. Kuwait (not Sinan’s group)<br />
42 MS patients had venoplasty and were signicantly worse at 1 year by relapse rate, EDSS
score and MRI .
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">El Sankari et al. France<br />
17 MS patients were compared to 12 normals with fast cine PC-MRI and showed no
differences.
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Denislic et al. Argentina<br />
Cadavers of 15 non-MS patients had normal extracranial veins.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Karmon et al. Zivadinov's group<br />
In 30 MS patients IVUS (intravenous ultrasound) was more sensitive to abnormalities than
catheter venography.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Dolic et al. Zivadinov’s Buffalo Group<br />
In 240 normals, heart disease, obesity and smoking increased the risk of Doppler ultrasound
abnormalities.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Zivadinov et al. Zivadinov’s Buffalo Group<br />
In 15 patients, venoplasty significantly improved CSF flow using a cine MRI method.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Hoogervorst et el Netherlands<br />
Of 14 MS patients 6 had CCSVI by color-Doppler ultrasound. No correlation was found
between these abnormalities and chronic fatigue measured by the Fatigue Severity Scale.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Burton and the Canadian CCSVI Systematic Review Group<br />
A literature search of 14 studies of CCSVI ultasound found a statistically significant association
with MS compared to normals.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Banwell et al. Toronto.<br />
Of 26 MS patients under age 18 only 2 met ultrasound CCSVI criteria.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Knox et al. Saskatoon, Canada.
</span><br />
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<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Blinded ultrasonographers found CCSVI in 4 of 5 MS patients, 0 of 10 with CIS, and 2 of 15
normals.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Zivadinov et al.<br />
Echo-color Doppler found CCSVI criteria in 53.9% of patients with "other" neurological diseases,
and 29.9% of normals.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Zivadinov et al.<br />
Ultrasound found CCSVI criteria in 43.5% of pediatric MS patients, 40% of patients with "other"
neurological diseases, and 30% of normals.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Simka. Poland<br />
In 126 MS patients and 13 normals, ultrasound was compared to catheter venography and
correlated poorly.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Visser et al. Netherlands<br />
Echo-color Doppler met CCSVI criteria in 8.9% of 90 MS patients and 0% of 41 normals.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Viola et al. Italy.<br />
Transcranial Brain Photoplethysmography, that measures microcirculation in capillaries and
venules, was used over the frontal lobes before and after 10second compression of both int.
jugular veins. Cerebral blood volume increase was 80.4% less in MS patients than normals,
suggesting lower flow-pressure posssibly due to CCSVI.
</span><br />
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;"><br /></span>
<span style="font-family: 'ArialMT'; font-size: 11.000000pt;">Blinkenberg et al. Denmark.<br />
In 24 MS patients, color Doppler, transcranial Doppler and phase-contrast MRI were all
essentially normal compared to 15 normals. </span><br />
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arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com4tag:blogger.com,1999:blog-2514232298104247719.post-29324470685682277252012-09-15T15:07:00.000-07:002012-09-15T15:07:29.651-07:00FDA Response to IDE request
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On Sept 9<sup>th</sup>, 2012 we finally received an FDA
response to our May 17<sup>th</sup> request for an evaluation of our on-going
CCSVI Multi-center Registry. <o:p></o:p></div>
<div class="MsoNormal">
The Agency has determined that our Registry is a “clinical
study,” that we must submit to them an IDE (investigational device exemption)
application, and that all enrollment of subjects must be suspended, although
already enrolled subjects should continued to be monitored. Other main points are as follows:<o:p></o:p></div>
<div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<!--[if !supportLists]--><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-size: 7pt;"> .</span></span></div>
<div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="font-family: 'Times New Roman'; font-size: 7pt;"> - </span></span>Each individual device (balloon or stent) must
be specified, including manufacturer.<o:p></o:p></div>
<div class="MsoListParagraphCxSpMiddle" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<!--[if !supportLists]--><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-size: 7pt;"> - </span></span><!--[endif]-->The procedure and post-procedure (e.g. Use of
blood thinners) must be standardized.<o:p></o:p></div>
<div class="MsoListParagraphCxSpMiddle" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<!--[if !supportLists]--><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-size: 7pt;"> - </span></span><!--[endif]-->The diseases to be treated (e.g. multiple
sclerosis, Parkinsons, Alzheimers, Migraine, Fatigue, Lyme disease) must be
standardized.<o:p></o:p></div>
<div class="MsoListParagraphCxSpMiddle" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<!--[if !supportLists]--><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-size: 7pt;"> -</span></span><!--[endif]-->The informed consent must be revised to
emphasize risk of death (we have not had any).<o:p></o:p></div>
<div class="MsoListParagraphCxSpLast" style="mso-list: l0 level1 lfo1; text-indent: -.25in;">
<!--[if !supportLists]--><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: 'Times New Roman'; font-size: 7pt;"> -</span></span><!--[endif]-->In addition, the Agency made suggestions
regarding our quality of life measure (SF-36vs) and the definition of “CCSVI.”<o:p></o:p></div>
<div class="MsoNormal">
<br /></div>
<div class="MsoNormal">
We plan to have a face-to-face meeting with the FDA and to
discuss these recommendations with the IRs (interventional radiologists)
participating in the Registry and hope to move forward quickly with an IDE
application. In the meantime, the only
IDE-approved study that may enroll CCSVI patients in North America is Dr.
Siskin’s at Albany Medical College.<o:p></o:p></div>
<!--EndFragment-->arleneotrhttp://www.blogger.com/profile/16357595777475546280noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-81151474938506013782012-05-30T10:49:00.000-07:002012-05-30T10:49:10.316-07:00Dr. McGuckin (Vascular Access Centers) dropping out of Multi-Center Registry<div dir="ltr" style="text-align: left;" trbidi="on">
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Citing concerns about the FDA warning, Dr. McGuckin has
notified the Hubbard Foundation that VAC is dropping out, and will no longer be
enrolling patients.<span style="mso-spacerun: yes;"> </span>We understand
that many of you who were treated through VAC may have concerns regarding
follow up data collection and treatment. We do not have any answers regarding
this as of yet, but this is a concern of ours as well. As we know more, we will
keep you updated.</div>
</div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com8tag:blogger.com,1999:blog-2514232298104247719.post-85414530050570422812012-05-30T10:44:00.000-07:002012-05-30T10:44:02.191-07:00Surprise FDA Inspection May 29, 2012<div dir="ltr" style="text-align: left;" trbidi="on">
FDA Site Visit<br /> <br /> May 29th, 2012, the FDA made a surprise visit to one
of our Multi-Center Registry sites. They asked to see all of our documentation and will be
returning again May 30th, 2012. They provided no information on the reason for
the visit or why that site was chosen first but did say that they would
be doing inspections “all over the country”. The FDA did not shut down
the site and as we have posted before we have alrea<span class="text_exposed_show">dy
applied to the FDA for an exemption. Although the FDA’s primary
intent is to prevent “advertising non approved uses for stents and
balloons” it is unclear, so far, whether they also will stop research
on CCSVI.</span><br />
<span class="text_exposed_show"><br /> The Hubbard Foundation intends to continue to collect data
on adverse events and changes in symptoms related to venoplasty (and
,hopefully, soon in relation to dietary and supplement interventions).
An analysis of our first 259 patients has been accepted for publication
and our multicenter Registry has collected data on over 400 people so
far. We can’t see why the FDA would not want this data to be collected
but we’ll keep you posted.</span></div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-78928383883761060422012-05-30T10:42:00.000-07:002012-05-30T10:42:13.643-07:00Letter to the FDA dated May 16th, 2012<div dir="ltr" style="text-align: left;" trbidi="on">
Letter to the FDA dated May 16th, 2012<br />
<br />
<br /><br />"In response to the FDA warning about CCSVI posted on the internet last week, I've attached our IRB-approved Multi-Center Registry and informed consent, and request that you review it for a pre-IDE and advise me as the sponsor on corrective action if appropriate. I have also attached our analysis of 259 patients that has been accepted for publication by a peer-reviewed medical journal. Although not a double-blind placebo-controlled study, we obtained MR venography and fMRI BOLD data that advances the science of underlying pathophysiology and diagnosis of venous insufficiency, had no serious adverse events and found statistically significant clinical improvement using the Multiple Sclerosis Impact Scale (MSIS-29). This study was performed at one site in San Diego, was approved by a local hospital IRB, has been completed and is no longer enrolling. Our on-going Multi-center Registry was approved by a national IRB, currently has 7 P.I.'s around the country, and has enrolled approximately 365 patients with symptoms of CCSVI, most but not all of whom have multiple sclerosis. You will note that the protocol does not allow recruitment or advertising as the use of venoplasty for neurological disease is not currently FDA approved. The protocol calls for completion of the Short-Form 36 quality of life questionnaire before and at 1, 6 and 12 months following venoplasty. The rationale for this Registry is that patients who choose to undergo this procedure should have a repository for collection of their adverse events and changes in their subjective symptoms, and that such a registry will assist in the design of blinded and placebo-controlled studies going forward.<br /><br />David Hubbard MD" (Hubbard Foundation, May 16, 2012)<br />
<br />
<br />
In response to this letter, the FDA assigned the Hubbard Foundation a pre-IDE document control number on May 17th, 2012. <br />
<br />
<br /></div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-9367591087560346902012-04-18T14:21:00.000-07:002012-04-18T14:21:42.473-07:00Hubbard Foundation Update April 18th 2012<div dir="ltr" style="text-align: left;" trbidi="on">Dr. Ponec and his North County Radiology team in San Diego, CA are no longer using the Del Mar Facility for CCSVI treatment. It has been bought out by a German dialysis company, and the IRs are now in the process of negotiating an acceptable treatment price from Pomerado Hospital, where Devin was treated. In addition, we have completed our functional MRI and perfusion study pre and post venoplasty. Our study of the first 260 patients has been accepted for publication, but we cannot publicize our data until the paper is published. Furthermore, our Multi-Center Registry for CCSVI Testing and Treatment is treating patients at 26 sites around the country and we are continuing to collect their data, having collected data on over 500 patients so far. You can find that information on the Hubbard Foundation web site. <a href="http://www.hubbardfoundation.org/">www.HubbardFoundation.org</a><br />
<br />
The Hubbard Foundation is focused on patient advocacy, education and expanding our research into dietary treatments and basic science studies. For those interested in coming to our center in San Diego, CA, we can test you in early May but we think it's risky to assume that Pomerado Hospital will agree to a lower treatment price by the conference then. We will have a lot more information at the conference, May 12th, including latest research findings from the Hubbard Foundation and other researchers. Please go to <a href="http://www.hubbardfoundation.org/">www.HubbardFoundation.org</a> for more information about the conference.<br />
<br />
If you have any questions email Arlene at <a href="mailto:Hubbardfoundationarl@gmail.com">HubbardFoundationArl@gmail.com </a><br />
</div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-56488064073306647242012-02-16T10:58:00.000-08:002012-02-16T10:58:38.443-08:00Hubbard's Cupboard- Healthy cooking for your body and mind!<div dir="ltr" style="text-align: left;" trbidi="on">Black Bean Fudge Brownies!?!<br />
<br />
Who would have thought to make a tasty dessert from beans.Well, check it out for yourself. <br />
<br />
Arlene Hubbard is the queen of healthy cooking, using organic ingredients, with high nutritional content, and <b>gluten-free</b> products! With lots of great tips to increase vascular and neurological health, this is not your every-day cooking video.<br />
<br />
Enjoy, stay well, and let's go with the flow!<br />
<br />
<iframe allowfullscreen="" frameborder="0" height="182" src="http://www.youtube.com/embed/QrDz_mco8-Q" width="300">&lt;p&gt;&amp;amp;amp;amp;lt;p&amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;lt;p&amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;br&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;Black Bean Fudge Brownies&amp;amp;amp;amp;amp;amp;amp;amp;lt;/p&amp;amp;amp;amp;amp;amp;amp;amp;gt;&amp;amp;amp;amp;lt;/p&amp;amp;amp;amp;gt;&lt;/p&gt;</iframe><br />
<br />
<span style="font-size: xx-small;">If you are allergic to any of the ingredients, this recipe is not for you.</span><br />
<br />
<a href="http://www.hubbardfoundation.org/">www.HubbardFoundation.org</a><br />
<br />
</div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com1tag:blogger.com,1999:blog-2514232298104247719.post-23070975705967112172012-01-18T14:24:00.000-08:002012-01-18T14:24:44.758-08:00MS and Heavy Metals<div dir="ltr" style="text-align: left;" trbidi="on"><div style="font-family: inherit;"><br />
The body has its own system to remove metal, but in some cases chelation therapy is used. For example, chelation removes heavy metals like lead in lead-poisoning. Some practitioners have considered chelation for MS as well, but Chelation IV is very controversial, speak to your health practitioner before starting any new regimen to look at the pros and cons. <br />
<br />
It is estimated that tens of thousands of people with MS in the US use chelation. There are two types of chelation: chelation IV, and oral chelation (oral chelation has not been proven to work as well). </div><div style="font-family: inherit;"><br />
</div><div style="font-family: inherit;"></div><div style="font-family: inherit;"></div><div style="font-family: inherit;">More resources, <a href="http://healthandwealthtoyoublog.com/uncategorized/pectasol-chelation-complex-review">Click Here</a></div><div style="font-family: inherit;"></div><div style="font-family: inherit;"><u></u></div><div style="font-family: inherit;"><u><br />
Foods that Help Remove Heavy Metals </u></div><div style="font-family: inherit;"><style>
</style></div><div style="font-family: inherit;"><style>
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</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">1.Cilantro</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">Cilantro mobilizes toxic metals from the central nervous system and other tissues. A researcher named Dr. Yoshiaki Omura, using bioenergetic measures, discovered that some patients excreted more toxic metals after consuming a Chinese soup containing cilantro. Cilantro is the leafy part of a common herb whose seed, coriander, is a familiar culinary spice. Its active component is a mercaptan that can penetrate the blood brain barrier.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit; text-align: justify;"><br />
</div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit; text-align: justify;"><span style="font-size: small;"> Cilantro stimulates the body's release of mercury and other heavy metals from the brain and CNS into other tissue. Cilantro’s postulated mechanism of action is to act as a reducing agent changing the charge on the intracellular mercury to a neutral state allowing mercury to diffuse down its concentration gradient into connective tissue.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><br />
</div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">2.Garlic</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">Garlic, contains both chelating amino acids L-methionine and L-cysteine, mobilizes and extracts cadmium, lead, arsenic and mercury within our bodies. </span><br />
<span style="font-size: small;"><a name='more'></a> </span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
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</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">3.Acetic acid is a natural substance found in fermented foods and drinks, i.e. sauerkraut, kimchi, kombucha, kvass, vinegar, etc.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><br />
</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">4.Citric acid is found in citrus fruits, i.e. lemons and limes.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><br />
</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">5.Ascorbic acid (vitamin C) is found in many foods including meats, vegetables and fruits.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><br />
</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">6.Lactic acid is found in dairy products, i.e. whey, kefir, and yogurt.</span></div><span style="font-family: inherit; font-size: small;"><span style="color: black;"> </span></span><br />
<div class="MsoNormal" style="color: black; font-family: inherit;"><br />
</div><div class="MsoNormal" style="color: black; font-family: inherit;"><span style="font-size: small;">7."Good" fats, such as butter, lard, unrefined coconut oil, and all natural occurring fats found in animals, eggs, and seafoods, along with protein from the same sources.</span></div><span style="font-size: small;"><span style="color: black;"> </span></span> </div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-87680054027640929972012-01-18T14:22:00.000-08:002012-01-18T14:23:37.181-08:00Heavy Metal Detox Pesto Recipe<div dir="ltr" style="text-align: left;" trbidi="on"><style>
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<div class="MsoNormal" style="color: black; line-height: 18pt;"><span style="font-family: Arial; font-size: 12pt;">Parsley and cilantro (corriander) are very powerful natural green plant foods for detoxing heavy metals out of your body. Add these amazing herbs to juices, salads, soups and meals. Mike Adams from Natural News talks more </span><span style="font-family: Helvetica; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 18pt;"><span style="font-family: Arial; font-size: 12pt;">about this also in the new upcoming 'Food Matters' film.</span><span style="font-family: Helvetica; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 18pt;"><br />
</div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 18pt;"><span style="font-family: Arial; font-size: 12pt;"><a href="http://www.foodmatters.tv/_webapp_513323/4_Simple_Detox_Tips_For_The_New_Year">http://www.foodmatters.tv/_webapp_513323/4_Simple_Detox_Tips_For_The_New_Year</a></span></div><div class="MsoNormal" style="color: black; line-height: 18pt;"><a href="http://1.bp.blogspot.com/-joQN-sZarHc/TxdF8sOS0fI/AAAAAAAAAww/6uE7wQXt1_A/s1600/cilantro-de.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="156" src="http://1.bp.blogspot.com/-joQN-sZarHc/TxdF8sOS0fI/AAAAAAAAAww/6uE7wQXt1_A/s200/cilantro-de.jpg" width="200" /></a><span style="font-family: Arial; font-size: 12pt;"> </span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 18pt;"><b><span style="font-family: Arial; font-size: 12pt;"> Heavy Metal Detox Pesto Recipe:</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">4 cloves garlic</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">1/3 cup Brazil nuts (selenium source) or macadamia nuts</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">1/3 cup sunflower seeds (cysteine source)</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">1/3 cup pumpkin seeds (zinc, magnesium sources)</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">1 cup fresh cilantro (corriander)</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">1 cup parsley</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">2/3 cup cold pressed olive oil</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">4 tablespoons lemon juice (Vitamin C source)</span></b><span style="font-family: Arial; font-size: 12pt;"></span></div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><span style="font-family: Arial; font-size: 12pt;">•<span style="font: 7pt "Times New Roman";"> </span></span><b><span style="font-family: Arial; font-size: 12pt;">Big pinch of sea salt and or dulse flakes to flavor</span></b></div><div class="MsoNormal" style="color: black; line-height: 21pt; margin-left: 0.5in; text-indent: -0.5in;"><br />
</div><span style="color: black;"> </span><br />
<div class="MsoNormal" style="color: black; line-height: 18pt;"><span style="font-family: Arial; font-size: 12pt;">Soak the seeds and nuts over night to release the enzyme exhibitors. Process the parsley, cilantro (corriander) and olive oil in a blender until chopped. Add the garlic, nuts, and seeds, salt / dulse and lemon juice and mix until the mixture is finely blended into a paste. Store in dark glass jars if possible. It freezes well also if needs be. Enjoy!</span></div></div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-43748599707882153652012-01-09T12:20:00.000-08:002012-01-09T12:20:06.546-08:00ISNVD Patient Day- Orlando, Florida<div dir="ltr" style="text-align: left;" trbidi="on">Don't miss the International Society for NeuroVascular Diseases' first MS Patient Day, February 18th in Orlando Florida. <br />
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There will be an overview of CCSVI, a roundtable discussion, and even some debates. David Hubbard MD, CCSVI research neurologist, will be discussing the research and theory with fellow neurologist Dr. Krolczyk. <br />
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<a href="http://3.bp.blogspot.com/-uAcHXr5kYY4/TwtLwhRW9rI/AAAAAAAAAwo/yywtZ7nroII/s1600/david_photo.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-uAcHXr5kYY4/TwtLwhRW9rI/AAAAAAAAAwo/yywtZ7nroII/s1600/david_photo.jpg" /></a><br />
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<a href="http://isnvd.org/index.php?site=patientday#content">http://isnvd.org/index.php?site=patientday#content</a></div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com0tag:blogger.com,1999:blog-2514232298104247719.post-28817206421732008512011-12-22T12:06:00.000-08:002011-12-22T12:06:49.529-08:00Video "CCSVI the Solution in Six Minutes"- David Hubbard MD<div dir="ltr" style="text-align: left;" trbidi="on"><iframe allowfullscreen="" frameborder="0" height="233" src="http://www.youtube.com/embed/2Iyl9LSkoJI" width="400"></iframe><br />
<br />
David Hubbard MD, Neurologist, Hubbard Foundation, speaks candidly about CCSVI and Multiple Sclerosis.<br />
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Please consider making a tax-deductible donation to support the Foundation's research and education this holiday season.<br />
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<a href="http://www.hubbardfoundation.org/support_the_hubbard_foundation.html">Click Here</a> to donate.<br />
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Thank you for your support and let's go with the flow!<br />
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Team Hubbard<br />
<a href="http://www.hubbardfoundation.org/">www.HubbardFoundation.org</a><br />
</div>Hubbard Foundationhttp://www.blogger.com/profile/11393742351493254157noreply@blogger.com4